Born at Oothcaloga in the Cherokee Nation, Georgia (near present day Rome, Georgia) on December 12, 1806, Stand Watie's Cherokee name was De-ga-ta-ga, or "he stands." He also was known as Isaac S. Watie. He attended Moravian Mission School at Springplace Georgia, and served as a clerk of the Cherokee Supreme Court and Speaker of the Cherokee National Council prior to removal.
As a member of the Ridge-Watie-boundinot faction of the Cherokee Nation, Watie supported removal to the Cherokee Nation, West, and signed the Treaty of New Echota in 1835, in defiance of Principal Chief John Ross and the majority of the Cherokees. Watie moved to the Cherokee Nation, West (present-day Oklahoma), in 1837 and settled at Honey Creek. Following the murders of his uncle Major Ridge, cousin John Ridge, and brother Elias Boundinot (Buck Watie) in 1839, and his brother Thomas Watie in 1845, Stand Watie assumed the leadership of the Ridge-Watie-Boundinot faction and was involved in a long-running blood feud with the followers of John Ross. He also was a leader of the Knights of the Golden Circle, which bitterly opposed abolitionism.
At the outbreak of the Civil War, Watie quickly joined the Southern cause. He was commissioned a colonel on July 12, 1861, and raised a regiment of Cherokees for service with teh Confederate army. Later, when Chief John Ross signed an alliance with the South, Watie's men were organized as the Cherokee Regiment of Mounted Rifles. After Ross fled Indian Territory, Watie was elected principal chief of the Confederate Cherokees in August 1862. Watie's two greatest victories were the capture of the federal steam boat J.R. Williams on June 15, 1864, and the seizure of $1.5 million worth of supplies in a federal wagon supply train a the Second battle of Cabin Creek on September 19, 1864. Watie was promoted to brigadier general on May 6, 1864, and given command of the first Indian Brigade. He was the only Indian to achieve the rank of general in the Civil War. Watie surrendered on June 23, 1865, the last Confederate general to lay down his arms.